Postdoctoral Researcher in the Field of Gene Regulation and Cancer
2 weeks ago
Organisation/Company: UNIVERSITY OF HELSINKI
Research Field: Biological sciences
Chemistry Researcher Profile: Recognised Researcher (R2) Established Researcher (R3)
Country: Finland
Application Deadline: 12 May 2025 - 00:00 (UTC)
Type of Contract: Other
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer DescriptionFaculty of Medicine, Barborič laboratory, invites applications for a position of Postdoctoral Researcher in the field of Gene Regulation by Cyclin-dependent Kinases and their Targeting in Cancer for a fixed-term. The position will be filled for a 2-year term starting at the earliest convenience.
Our mission
The lab's mission is to unravel fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in essential and biomedically important transcriptional cyclin-dependent kinases (tCDKs) that trigger release of Pol II from promoter-proximal pausing and facilitate productive Pol II elongation along gene bodies.
We are looking for a creative thinker with strong analytical skills and a passion for science. We expect you to formulate your own hypotheses, propose experimental designs to address them, and take advantage of the laboratory/research community's intellectual and skill resources to advance the knowledge of the field.
Qualifications
The competitive candidate should hold a PhD degree in molecular biology, biochemistry, cancer biology, or related fields. Expertise in biochemistry, transcriptomics, NGS data analysis, and basic programming in R/Python is a pre-requisite for the position. Previous experience of working with in vivo models of cancer is considered an advantage. Strong command in written and spoken English is required.
The chosen applicant is expected to reside in Finland while employed by the University of Helsinki.
What we offer
The successful candidate will receive training in biochemical, molecular biology, and cell line-based functional assays, as well as cutting-edge systems biology methods, such as CRISPRi and nascent transcriptomics methods. The training could be furthered by research visits within our collaboration network of well-regarded laboratories around the globe. Current projects in the lab funded by Research Council of Finland, Sigrid Juselius Foundation, and Cancer Foundation Finland grants revolve around the fundamental biology of tCDKs and their combinatorial targeting in cancer.
The appointment will be initially for two years with a possibility for extension. A trial period of six months will be applied. The monthly gross starting salary will be approximately 3700 € per month, depending on the appointees' qualifications and experience.
In addition, the University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Please read more at University of Helsinki Careers.
How to apply
Applications should be submitted through the University of Helsinki Recruitment System via the "Apply now" button.
Internal applicants (i.e., current employees of the University of Helsinki) submit their applications by using the Employee Login button.
Please send your application with the following appendices:
- A complete CV, including PhD thesis title and date of defense, previous and current positions, academic distinctions, teaching, and committee work.
- A complete list of publications.
- Two letters of reference.
The closing date for applications is May 12, 2025. The shortlisted candidates will be notified about the interview shortly afterwards.
For further information on the position, please contact Matjaž Barborič, Ph.D.; matjaz.barboric (at) helsinki.fi.
Applicants of any gender, linguistic and cultural background, or from members of minority groups are welcomed.
The Faculty of Medicine promotes high-quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology, and logopedics, and an international Master's Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organization in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare: Faculty of Medicine.
The Faculty of Medicine at the University of Helsinki constitutes the academic medical center together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical center has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.
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Helsinki, Uusimaa, Finland Helsingin yliopisto Full timeFaculty of Medicine, Barborič laboratory, invites applications for a position ofPostdoctoral Researcherin the field of Gene Regulation by Cyclin-dependent Kinases and their Targeting in Cancer for a fixed-term. The position will be filled for a 2-year term starting at the earliest convenience.Our missionThe lab's mission is to unravel fundamental mechanisms...
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